Scientist
Application Deadline: 28 November 2026
Department: Scale Enabling Technologies
Employment Type: Permanent - Full Time
Location: London (Guy's hospital)
Description
The purpose of this role is to support the development of novel cell and gene therapy medicinal products and associated technologies for multiple clients and Collaborators. Working in multidisciplinary teams, this role will play a central role in the delivery of projects, applying indepth technical expertise to accelerate the development and translation of ATMPs and associated technologies.
Key Responsibilities
- Working in a matrix-team environment contribute expertise and influence the design and planning of laboratory work across multidisciplinary projects
- Provide subject matter expertise in PSC biology
- Apply knowledge of analytics and characterisation of PSCs, differentiated cell types andother cell types to sample analysis, analytical development and analytical automation
- Undertake laboratory-based development activities across a range of projects applying expert knowledge of PSC and developmental biology to characterise and optimise PSC expansion and differentiation processes
- Aid the translation of research-based manufacturing processes and analytical methods to clinical manufacturing and QC protocols that will become suitable for commercial use
- Keep up to date with technological and scientific progress in the PSC and cell therapy field
- Plan, write and execute scientific protocols, maintain accurate records and manage data in line with company policies
- Record, analyse and communicate experimental findings in electronic laboratory notebooks, scientific reports, posters and peer-reviewed publications and present results internally and to external collaborators
- Maintain high standards of laboratory practices in all development activities
Experience:
- Excellent experience of PSC developmental biology, with practical experience in the maintenance, expansion and differentiation of PSCs in 2D and 3D culture systems, is essential
- Demonstrable experience in mammalian cell culture and the use of aseptic techniques is essential
- Experience in the development and application of analytical characterisation techniques for allogeneic cell therapy products and intermediates is essential
- Experience with development, optimisation, automation and application of a wide range of molecular biology and cell-based methods, with a particular focus on flow cytometry, is essential
- Experience of evaluating and implementing new technologies to improve workflows and process efficiency is essential
- Demonstrable experience of troubleshooting, developing or optimising PSC differentiation protocols is highly desirable
- Experience of operating liquid handlers and the development of new automation workflow(particularly through scripting) is highly desirable
- Experience of statistical tools such as method validation and/or Design of Experiments (DoE) to drive efficient and robust experimental design is desirable
- Experience in product development/release is desirable
- Experience in translational research is desirable
Skills, Knowledge and Expertise
- Highly motivated, pragmatic, and practical to support the mission of the Cell and Gene Therapy Catapult to accelerate the development of a commercial cell and gene therapy industry in the UK
- Desire to establish a high-profile career within cell and gene sector and the personal drive to help push the sector to be a commercial success
- High-level interpersonal, communication (oral and written) skills and emotional intelligence
- Resilient, with the ability to manage multiple and varied tasks and prioritise workload within a fast-paced professional environment, with a strong attention to detail
- Flexible and pragmatic, able to learn quickly and respond flexibly to project needs and priorities
- A good team player with a “roll your sleeves up” hands-on approach, and adaptable to new challenges
- Proficient in Microsoft 365 applications and general IT systems
- Ambitious, collaborative, driven
- Ability to work well under pressure, to work independently once goals and objectives are set and to be able to take the initiative when completing tasks
- A positive attitude towards learning, personal and professional development
- Keeps up to date with professional knowledge, expertise and best practice
- Willingness to travel as required by the role
Education / Qualifications:
- PhD in stem cell therapy/stem cell or developmental biology or MSc with extensive industrial experience within a stem cell therapy/stem cell or developmental biology environment
